Environmental Health and Engineering Grand Rounds: The Context Makes the Poison: Exposomics and the Future of Toxicology

The old paradigm that the dose makes the poison still holds, but does not capture the complexity of biology, medical care, and disease pathology. It is clear that context also makes the “poison”- i.e. the setting in which exposure occurs. Nutritional status, co-chemical exposures, social stressors, physical stressors, life stage at exposure, and presence of concurrent disease all modify the dose-response curve and can even occur as a highly complex mixture over time (multi-hit hypotheses). A broad definition of exposomics allows researchers to incorporate these factors, and in this presentation, a case is made that the Human Exposome Map will be a key research tool to address all forms of context.

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